deauville score hodgkin lymphoma

; Mostafa, H.M.; Elsayed, H.F.; Abo-ElAzm, O.M. Pretransplant Deauville score (DS) is an imaging biomarker used for risk stratification in relapsed/refractory classical Hodgkin lymphoma (cHL). was considered. Support Center Find answers to questions about products, access, use, setup, and administration. We aimed to compare the performance of SUV, Hodgkin lymphoma (HL) is now one of the most curable forms of neoplasms in children. Sherief, L.M. To test the reliability of each feature, different feature reduction methods were applied. ; writingoriginal draft preparation, F.I. The 5-point scoring system (5p Deauville Score, 5p-DS) has been widely accepted, and it has been proposed as a rapid qualitative method to evaluate interim FDG-PET/CT through visual comparison between the uptake within residual lymphoma tissue to the reference regions mediastinum and liver. Med. All Patients fasted for6h before 18F-FDG injection and a blood glucose level of<190mg/dl was ensured. In their approach, Giesel et al. Ferrari, C.; Niccoli Asabella, A.; Merenda, N.; Altini, C.; Fanelli, M.; Muggeo, P.; De Leonardis, F.; Perillo, T.; Santoro, N.; Rubini, G. Pediatric Hodgkin lymphoma: Predictive value of interim. Hodgkin lymphoma typically appears in the supradiaphragmatic lymph nodes. 1, 2, 3, 4, 5, 6 However, individuals who survive are at a high risk of secondary cancers and cardiovascular disease after chemoradiotherapy. The Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the fluorodeoxyglucose (FDG) avidity of a Hodgkin lymphoma or Non-Hodgkin lymphoma tumor mass as seen on FDG positron emission tomography:[1], Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. Purpose: 2019;14:353-68. https://www.ijnm.in/text.asp?2023/38/1/16/370409, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, 2008 Indian Journal of Nuclear Medicine | Deauville five-point score (DS) is recommended for response assessment in international guidelines. The Lugano classification system further modified staging by incorporating positron emission tomography/computed tomography (PET-CT) results to determine the staging of the lymphoma, Patients should follow up with an oncologist every three to six months for the first two years. Editors select a small number of articles recently published in the journal that they believe will be particularly Pretransplant DS was determined as 1-3 (59%) and 4-5 (41%), with a markedly inferior event-free survival (EFS) in patients with DS 4-5 (hazard ratio [HR], 3.14; p = .002). In the meantime, to ensure continued support, we are displaying the site without styles WebLung cancer is the leading cause of cancer-related mortality globally, and lung adenocarcinoma is the most frequent histologic subtype [ 1 ]. Semin Ultrasound CT MR 2010;31:496-505. ; Sherbiny, H.S. Incidence of non-Hodgkin lymphoma is higher in men and whites, and it increases with age. Nucl. 32, 30593068. 18F-Fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) is the standard diagnostic test for end-of-treatment assessment in Hodgkin lymphoma1, which accounts for 10% of all diagnosed lymphomas2. Diagnostic value of baseline 18FDG PET/CT skeletal textural features in follicular lymphoma, Comparison of different automatic methods for the delineation of the total metabolic tumor volume in III stage Hodgkin Lymphoma, A PET Radiomics Model to Predict Refractory Mediastinal Hodgkin Lymphoma, Comparison of whole-body MRI, bone scan, and radiographic skeletal survey for lesion detection and risk stratification of Langerhans Cell Histiocytosis, Proposal for a Quantitative 18F-FDG PET/CT Metabolic Parameter to Assess the Intensity of Bone Involvement in Multiple Myeloma, Intensity harmonization techniques influence radiomics features and radiomics-based predictions in sarcoma patients, Investigation of radiomics based intra-patient inter-tumor heterogeneity and the impact of tumor subsampling strategies, Combined whole-lesion radiomic and iodine analysis for differentiation of pulmonary tumors, Radiomics Features Differentiate Between Normal and Tumoral High-Fdg Uptake, https://doi.org/10.1053/j.semnuclmed.2017.09.007, https://doi.org/10.1182/blood-2018-05-852129, https://doi.org/10.1080/10428190903040048, https://doi.org/10.1038/s41598-020-68310-w, https://doi.org/10.1016/j.ymeth.2020.05.022, https://doi.org/10.1038/nrclinonc.2017.141, https://doi.org/10.1016/j.ymeth.2020.06.020, https://doi.org/10.1038/s41598-018-37197-z, https://doi.org/10.1007/s00330-016-4470-8, https://doi.org/10.1097/RLU.0000000000002732, https://doi.org/10.1038/s41598-021-81526-8, https://doi.org/10.1038/s41598-018-31509-z, https://doi.org/10.1186/s40658-019-0244-0, https://doi.org/10.1186/s40658-020-0270-y, https://doi.org/10.1016/j.mri.2012.05.001, https://doi.org/10.1007/s00259-014-2715-9, https://pyradiomics.readthedocs.io/en/latest/features.html, https://doi.org/10.1158/0008-5472.CAN-17-0339, https://doi.org/10.1148/radiol.2020191145, https://doi.org/10.1037//0033-2909.86.2.420, https://doi.org/10.1016/j.softx.2021.100819, https://doi.org/10.1080/10428194.2020.1786555, https://doi.org/10.1148/radiol.2018172361, https://doi.org/10.1007/s00259-021-05233-2, https://doi.org/10.2967/jnumed.116.179648, https://doi.org/10.1007/s11307-017-1155-x, https://doi.org/10.1007/s11307-022-01703-7, https://doi.org/10.1038/s41598-021-03278-9, https://doi.org/10.1038/s41598-022-13967-8, http://creativecommons.org/licenses/by/4.0/. The most common subtype, diffuse large B-cell lymphoma, has a 40% lifetime relapse rate.37 Lifetime relapse in Hodgkin lymphoma occurs in 10% to 15% of patients with early stage disease and 40% of patients with advanced stage disease.38, Patients who have achieved remission need routine surveillance to monitor for complications and relapse, as well as age-appropriate screenings recommended by the U.S. Preventive Services Task Force.39 Complications of lymphoma treatment include secondary malignancies (e.g., breast, lung, skin, colon), cardiac disease, infertility, and endocrine, neurologic, and psychiatric dysfunctions. Diagn. False-positive patients showed evidence of disease at interim PET-CT imaging but remained in remission during follow-up. 2023, 13, 445. Radiomics is a modern approach that allows quantitative assessment of medical images beyond apparent morphologic features10. ROC curves of these features are presented in Fig. WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. qPETa quantitative extension of the Deauville scale to assess response in interim FDG-PET scans in lymphoma. 10 Results showed superior results for patients who were PET negative. Post-therapy DS showed a sensitivity, specificity, PPV, NPV and accuracy of 66.7%, 97.8%, 95.7%, 80% and 94.2%, repsectively. ; Kamal, N.M.; Elbehedy, R.; Hassan, T.H. Repeatability and reproducibility study of radiomic features on a phantom and human cohort. ; All authors have read and agreed to the published version of the manuscript. It usually responds well to combination therapy, justifying the need for clinicians to know when to intensify therapy in poor responders or to maintain or deescalate it in responders. You seem to have javascript disabled. The International Prognostic Index is used broadly for all subtypes of non-Hodgkin lymphoma, and the International Prognostic Score is used for Hodgkin lymphoma20,21 (Table 422,23). Follows et al, British Journal of Haematology, 2014, 166, 3449. Epub 2016 Mar 2. HHS Vulnerability Disclosure, Help ; Metzger, M.L. The feature median from NECT concordantly has a high sensitivity for DS4+ Hodgkin manifestations on two different scanners and thus could provide a surrogate for increased metabolic activity in PET/CT. As an alternative, we investigated radiomics from non-contrast-enhanced computed tomography (NECT) scans. ; supervision, S.N.N. Interv. Aims: We aimed to validate DS in Hodgkin's lymphoma (HL) by retrospectively assigning this score to F-18 FDG PET-computed tomography (CT) studies done before 2016 and analyzing its concordance with the line of management. The generalizability and clinical applicability should be evaluated on data from a second PET/CT scanner. Harell, F. Jr. Hmisc: Harrell Miscellaneous. Performance of Philips Gemini TF PET/CT scanner with special consideration for its time-of-flight imaging capabilities. ; Erdrich, A.S.; Hundsdoerfer, P.; Ruf, J.; Henze, G.; Schnberger, S.; Amthauer, H.; Hautzel, H. Explorative analyses on the value of interim PET for prediction of response in pediatric and adolescent non-Hodgkin lymphoma patients. Vandendriessche, D., Uribe, J., Bertin, H. & De Geeter, F. Performance characteristics of silicon photomultiplier based 15-cm AFOV TOF PET/CT. Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). A family history of a specific subtype of lymphoma is associated with developing that same subtype.5 There are three main mechanisms through which infection increases lymphoma risk: direct transformation of lymphocytes, immunosuppression, and chronic antigenic stimulation6 (Table 26,7). ; writingreview and editing, F.I., M.G., L.F.; supervision, S.P., D.C., E.N. Role of imaging in the staging and response assessment of lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working Group. Provided by the Springer Nature SharedIt content-sharing initiative. J. Pers. Oncol. All PET-CT parameters were strongly associated with the Deauville score (P<.001) and FFP (P<.0001) on univariate analysis. High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkins disease: Report from the Late Effects Study Group. Target lesions were classified as Deauville score 4 positive (DS4+) or negative (DS4) based on their SUVpeak and then segmented in NECT images. In order to be human-readable, please install an RSS reader. For example, Ganeshan et al. Therefore, interreader agreement was assessed to drop low-reproducible features, and different feature reduction methods were performed to reduce the number of variables. Required fields are marked *. DS gives the threshold for adequate or inadequate response to be adapted according to the clinical context or research question. Mayerhoefer, M. E., Umutlu, L. & Schoder, H. Functional imaging using radiomic features in assessment of lymphoma. Radiotherapy can also lead to long-term complications, including cardiac and pulmonary toxicity, hypothyroidism, or breast or lung cancers.2432 Radiotherapy can be avoided in patients with stage IA or IIA lymphoma without bulky disease25 (Table 319). ; resources, F.I., A.R.V. Data Sources: A PubMed search was completed using combinations of the key terms lymphoma, non-Hodgkin, Hodgkin, presentation, diagnosis, staging, treatment, and follow up. Informed consent was obtained from all subjects involved in the study. Lymphoma typically presents as painless adenopathy, with systemic symptoms of fever, unexplained weight loss, and night sweats occurring in more advanced stages of the disease. Standard of Care is available as a free resource for practicing medical professionals, students and the general public. Methods: Barrington, S. F. et al. Berenguer, R. et al. Comprehensive investigation on controlling for ct imaging variabilities in radiomics studies. Furth, C.; Steffen, I.G. Accessibility Would you like email updates of new search results? Four patients were PET positive at the end of ABVD An official website of the United States government. Current paradigm of response to therapy in Hodgkins lymphoma. Prognostic significance of interim PET/CT response for the treatment of advanced-stage marginal zone lymphoma in the post-rituximab era. Google Scholar. Linch DC, Winfield D, Goldstone AH, et al. https://doi.org/10.1038/nrclinonc.2017.141 (2017). Results: Among 212 scans assigned DS, 165 scans showed agreement between the DS and line of treatment. PubMed Central We tested features for inter-reader agreement separately for each scanner by calculating ICCs (ICC3 according to the Shrout and Fleiss Convention31) using the psych package for R32 (Version 2.2.5). Particularly, there was a significant difference in PFS between patients with interim score 12 and those with score 3. https://doi.org/10.1148/radiol.2018172361 (2018). WebThe Deauville scoring (DS) system is the current standard for PET response assessment in FL and quantitative criteria, such as SUVmax, have demonstrated the ability to identify the highest risk patients in other lymphoma subtypes. Cheson, B.D. Eur. Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E. Biggi A, Gallamini A, Chauvie S, Hutchings M, Kostakoglu L, Gregianin M. Haioun C, Itti E, Rahmouni A, Brice P, Rain JD, Belhadj K. Hutchings M, Barrington SF. Isik, E.G. Mol. Kuhn, M. caret: Classification and Regression Training. Annunziata, S.; Cuccaro, A.; Calcagni, M.L. Interestingly, even in NECT images, the feature median that ultimately describes the density of a lymphoma manifestation differentiated between DS4-positive and DS4-negative lesions, thereby showing constantly higher values in DS4-positive manifestations (numerical results of the radiomics analysis are provided in the supplementary Table S3; S3a for scanner A and S3b for scanner B). After a lifetime of experience as a practicing medical professional, Dr. Stephen Cohen has created a repository of insightful medical information. However, the prognostic value Imaging Biol. Editors Choice articles are based on recommendations by the scientific editors of MDPI journals from around the world. ), or their login data. PET data from scanner B were reconstructed iteratively with Bayesian penalized likelihood reconstruction (GE Q.Clear) with a penalization factor of 450, which included time of flight analysis and point spread function modeling21. Imaging in staging of malignant lymphoma: A systematic review. Med. Clipboard, Search History, and several other advanced features are temporarily unavailable. Neither SUV interim nor qualitative assessment of Deauville score has predictive value for HT. J. Nucl. PET scan followed after a median uptake time of 68min (IQR, 63.576.5min). ; Diller, L.; DeLaat, C.; Fossati-Bellani, F.; Morgan, E.; Oberlin, O.; et al. A score of 4 or 5 is an indicator to consider escalating therapy. PET-positive suture granuloma of abdominal wall 56 years post-appendicectomy mimicking recurrence of MDPI and/or sharing sensitive information, make sure youre on a federal SUV max reduction (SUV max) and tumor/liver ratio (TLr) are promising tools for response assessment in lymphoma.We determined the optimal cutoff values for SUV max and TLr and ; visualization, S.N.N., L.J.J. WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Considering the dataset of scanner B, this accounted for 26 features. Prediction of outcome in pediatric Hodgkin lymphoma based on interpretation of. ; Vant Veer, M.B. permission provided that the original article is clearly cited. Patients were followed up with clinical examinations and biochemical tests (including serum LDH levels). The settings used for feature extraction can be found in the supplementary file S2a, the IBSI reporting guidelines and the checklist in the supplementary file S2b. J. Nucl. CT radiomics to predict Deauville score 4 positive and negative Hodgkin lymphoma manifestations, https://doi.org/10.1038/s41598-022-24227-0. Conceptualization, F.I. 27, 10121020. Reson. Rep. 11, 23812. https://doi.org/10.1038/s41598-021-03278-9 (2021). Kaste, S.C.; Howard, S.C.; McCarville, E.B. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. WebWhat is a good Deauville score? This articledid not receive any funding. Performing texture analysis with a non-contrast-enhanced CT is also less expensive and time-consuming than PET/CT. Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. https://doi.org/10.1158/0008-5472.CAN-17-0339 (2017). Lue, K. H. et al. Furth, C.; Steffen, I.G. Eligible patients were age 18-60 years with 1 unfavorable EORTC/LYSA criterion. 2018 Dec;24(12):2501-2508. doi: 10.1016/j.bbmt.2018.07.025. Barrington SF, Kirkwood AA, Franceschetto A, Fulham MJ, Roberts TH, Almquist H. Barrington SF, Qian W, Somer EJ, Franceschetto A, Bagni B, Brun E. Itti E, Meignan M, Berriolo-Riedinger A, Biggi A, Cashen AF, Vra P. Cheson BD, Ansell S, Schwartz L, Gordon LI, Advani R, Jacene HA. Unauthorized use of these marks is strictly prohibited. Giesel, F. L. et al. Radiol. ; resources, H.A. WebOne of the limitations of 18 FDG PET/CT for therapeutic evaluation in Hodgkin's Lymphoma is the relatively high rate of false positive uptake. Rep. 11, 2055. https://doi.org/10.1038/s41598-021-81526-8 (2021). Article Validation of deauville score for response evaluation in hodgkin's lymphoma https://doi.org/10.1200/JCO.2013.53.5229 (2014). PET/CT for therapy response assessment in lymphoma. National Library of Medicine Straus DJ, Dugosz-Danecka M, Connors JM, Alekseev S, Ills , Picardi M, Lech-Maranda E, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Ramchandren R, Zinzani PL, Hutchings M, Munoz J, Lee HJ, Kim WS, Advani R, Ansell SM, Younes A, Gallamini A, Liu R, Little M, Fenton K, Fanale M, Radford J. Lancet Haematol. The data can be made publicly available on reasonable request. N Engl J Med. The Infona portal uses cookies, i.e. Younes A, Santoro A, Shipp M, et al. ; methodology, F.I. Younes A, Gopal AK, Smith SE, et al. ; Barrington, S.F. This research received no external funding. https://www.mdpi.com/openaccess. 2016 Sep;95(9):1521-35. doi: 10.1007/s00277-016-2736-5. Article All patients with lymphoma should receive pneumococcal vaccination initially with a 13-valent pneumococcal conjugate vaccine (Prevnar 13), followed at least eight weeks later by a 23-valent pneumococcal polysaccharide vaccine (PPSV23; Pneumovax 23) and then another PPSV23 at least five years later. [2]. and B.H. Exp Hematol Oncol. 18F-FDG-PET/CT is standard to assess response in Hodgkin lymphoma by quantifying metabolic activity with the Deauville score. Our study has some limitations. ; software, A.R.V. https://doi.org/10.1007/s11307-017-1155-x (2018). J. Pers. Epidemiology of Hodgkins disease and non-Hodgkins lymphoma. ; Hussein, M.H. More than 82,000 new patients are projected to be diagnosed with lymphoma in 2019, representing 4.7% of all new cancer cases in the United States. We tested all features scanner-wise for their diagnostic performance to evaluate if and which similarities exist between both datasets (single feature diagnostic performance). Since these are acquired shortly before the PET images, this results in only a short temporal gap to the reference standard. The World Health Organizations classification system identifies more than 90 different subtypes (Table 1).1,2 The initial stratification is derived from B-cell, T-cell, or natural killer cell origin. By submitting a comment you agree to abide by our Terms and Community Guidelines. This site needs JavaScript to work properly. WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Patient-related examination details and distribution of Deauville Scores are listed in Table 2. Deauville score calculation involves consideration of various individual scores: SUVmax. Considering the results of the MWU test, 41 features from the dataset of scanner A and eight from the dataset of scanner B showed a significant difference between DS4-positive and DS4-negative lesions. B symptoms (fevers, night sweats, weight loss) occur in up to 30% of patients; more common in advanced disease. However, most extant studies on PET and the treatment response in patients with lymphoma have been performed in the adult population, and their findings have often been extended to pediatric patients without clear evidence whether the visual interpretation of. High rMTV41% (rMTVhigh , 4.4 cm3 ) predicted significantly poorer EFS in patients with DS 4-5 (HR, 3.70; p = .014). WebDeauville scores improve the clinical utility of end-of-chemotherapy PET, as evidenced by an increase in positive predictive value to 72.7% from 44.4% on the basis of report alone. Web Close. We decided to analyze NECTs obtained for the PET attenuation correction. Rogasch, J. M. et al. Junita Rachel John1, Regi Oommen1, Julie Hephzibah1, David Mathew1, Anu Korula2, Nylla Shanthly1, Anu Eapen3 and D.K. If clinical suspicion of recurrence was present, repeat PET-CT was performed. AJR Am J Roentgenol 2019;212:456-60. Sci. Approximately 82,000 new U.S. patients are diagnosed with lymphoma annually. The .gov means its official. Ger, R. B. et al. Aleman, B.M.P. Rep. 12, 10192. https://doi.org/10.1038/s41598-022-13967-8 (2022). ; writingoriginal draft preparation, L.J.J. J Clin Oncol. Sci. ; Abdelkhalek, E.R. Swerdlow, A.J. A p-value<0.05 was generally considered to indicate statistical significance. The author has an hindex of 2, co-authored 11 publication(s) receiving 8 citation(s). Korula A, Fouzia NA, Devasia A, Kulkarni U, Abraham A, Srivastava A. Bair SM, Svoboda J. Response-Adapted Treatment Strategies in Hodgkin Lymphoma Using PET Imaging. Meignan M, Gallamini A, Meignan M, Gallamini A, Haioun C. Report on the first international workshop on interim-PET-scan in lymphoma. WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. PET/CT, however, is time In a multivariable analysis, we identified two independent factors predicting treatment failure: pretransplant DS combined with rMTV41% and disease status (primary refractory vs. relapsed). ; project administration, S.N.N. WebThe blood level of lactate dehydrogenase (LDH), which goes up with the amount of lymphoma in the body Each poor prognostic factor is assigned 1 point. Kobe, C. et al. Open lymph node biopsy should be used to definitively diagnose lymphoma. and I.G.S. Bethesda, MD 20894, Web Policies PET/CT, however, is time-consuming, cost-extensive, linked to high radiation and has a low availability. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. The resulting areas under the curve (AUCs) were rated as follows: 0.700.80 acceptable, 0.800.90 excellent, 0.901.00 outstanding diagnostic performance30. Comparison of first-line chemotherapy including escalated BEACOPP versus chemotherapy including ABVD for people with early unfavourable or advanced stage Hodgkin lymphoma. 77, e104e107. Such data are somewhat different from a previous study conducted on 68 adult HL patients, reporting a sensitivity of 53% and a specificity of 95% with a cut-off of 1.14 [, For interim PET-CT, a statistically significant association was found in the specificity and false-positive rates when SUV, One limitation of our study was its small sample size and relatively short follow-up time. future research directions and describes possible research applications. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Conceptualization, S.N.N. Readers were required to include as much lymphoma manifestation as possible while keeping a distance of 12 pixels from the edge. J Nucl Med 2009;50 Suppl 1:21S-30S. PubMed An official website of the United States government. https://doi.org/10.3390/jpm13030445, Ibrahim F, Gabelloni M, Faggioni L, Padma S, Visakh AR, Cioni D, Neri E. Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma? For each feature, differences between the DS4-positive and DS4-negative group were tested scanner-wise for statistical significance using the MannWhitney U-test (MWU) from the R stats package28 (part of R). Slider with three articles shown per slide. Eur. To achieve reproducible results, we determined the final DS using the qPET approach23. 2012;30(18):2183-2189. Radiomics of CT features may be nonreproducible and redundant: Influence of CT acquisition parameters. Bhatia, S.; Yasui, Y.; Robison, L.L. Patients should follow up with an oncologist every three to six months for the first two years, every six to 12 months until year 3, then annually thereafter. To address this issue, we used data from two scanners to test the generalizability of our results. Prognostic significance of baseline metabolic tumor volume in relapsed and refractory Hodgkin lymphoma. CAS 8600 Rockville Pike PubMed Central 48, 7681. https://CRAN.R-project.org/package=psych. Shao et al. Phys. Connors JM, Jurczak W, Straus DJ, Ansell SM, Kim WS, Gallamini A, Younes A, Alekseev S, Ills , Picardi M, Lech-Maranda E, Oki Y, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Chen R, Ramchandren R, Zinzani PL, Cunningham D, Rosta A, Josephson NC, Song E, Sachs J, Liu R, Jolin HA, Huebner D, Radford J; ECHELON-1 Study Group. 2013 Dec;14(13):1348-56. doi: 10.1016/S1470-2045(13)70501-1. Bull. After five years of being cancer free, the patient can be transitioned to a primary care physician.40, If a patient is asymptomatic, routine surveillance imaging does not improve outcomes or provide a clinical benefit.40,41 Surveillance imaging should be used in patients who have reported symptoms or who are at high risk of relapse in a place that would not be easily examined, and who would be candidates for treatment. Google Scholar. Radiology 295, 328338. Prognostic value of pretreatment radiomic features of 18F-FDG PET in patients with hodgkin lymphoma. Patient information: See related handout on lymphoma, written by the authors of this article. sharing sensitive information, make sure youre on a federal doi: 10.1002/14651858.CD007941.pub3. Hasenclever, D. et al. We retrospectively assessed 106 patients with relapsed/refractory cHL who underwent autologous stem cell transplantation. Beyond that, by extracting features from NECT images, we can exclude interferences with the contrast agent, dose, and timing of the image acquisition. 41, 121904. https://doi.org/10.1118/1.4900821 (2014). Federal government websites often end in .gov or .mil. Jerusalem G, Beguin Y, Fassotte MF, Najjar F, Paulus P, Rigo P. Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM. FDG-PET after two to three cycles of chemotherapy predicts progression-free and overall survival in high-grade non-Hodgkin lymphoma. The physician should focus on shared decision-making when discussing treatment options with all patients, but particularly for those older than 60 years, including whether the patient should pursue treatment.25, The standard treatment for Hodgkin lymphoma is ABVD (doxorubicin [Adriamycin], bleomycin, vinblastine [Velban], and dacarbazine), but other regimens such as the Stanford V (doxorubicin, vinblastine, mechlorethamine, etoposide [Toposar], vincristine, bleomycin, and prednisone) and escalated-BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine [Matulane], and prednisone) can be used.2428 Treatment for non-Hodgkin lymphoma varies depending on the histology, but often uses treatments such as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab (Rituxan; R-CHOP), a monoclonal antibody specific for CD20-positive B lymphocytes.29 Other medications such as bendamustine (Bendeka), an alkylating agent, and lenalidomide (Revlimid) are also used in many non-Hodgkin lymphoma treatments.30,31 Common complications of these therapies are listed in Table 5.2527,2936. The metabolic activity in PET/CT is usually assessed with the Deauville Score (DS), a 5-point system to categorize FDG avidity. However, if the lesion was difficult to delineate on the NECT images, the lesion with the next lower or comparable DS was considered. Julie Faudemer, Nicolas Aide, Charline Lasnon, Queralt Martn-Saladich, Gabriel Reyns-Llompart, Montse Corts-Romera, Sarah A. Milgrom, Hesham Elhalawani, Grace L. Smith, Jeong Rye Kim, Hee Mang Yoon, Jin Seong Lee, Maria E. S. Takahashi, Camila Mosci, Celso D. Ramos, Amandine Cromb, Michle Kind, Olivier Saut, Lea Azour, Jane P. Ko, William H. Moore. BMC Bioinf. ; Hudson, M.M. A metaanalysis of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography in the staging and restaging of patients with lymphoma. Fedorov, A. PubMedGoogle Scholar. The Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the fluorodeoxyglucose (FDG) avidity of a Hodgkin lymphoma or Non-Hodgkin lymphoma tumor mass as seen on FDG positron emission tomography: The Spearman between Deauville score and SUV max approach was 0.31 (95% CI, 0.230.38). At the end of ABVD an official website of the U.S. Department of Health and human...., S.P., D.C., E.N Metzger, M.L copy of this article rated as:. Order to be human-readable, please install an RSS reader low-reproducible features, and increases. A lifetime of experience as a deauville score hodgkin lymphoma resource for practicing medical professional, Dr. Stephen Cohen created... Consent was obtained from all subjects involved in the staging and response assessment of medical images apparent! Of page numbers we used data from a second PET/CT scanner Metzger, deauville score hodgkin lymphoma generalizability of our.! First-Line chemotherapy including ABVD for people with early unfavourable or advanced stage Hodgkin lymphoma Sherbiny H.S... Categorize FDG avidity computed tomography ( NECT ) scans in relapsed/refractory classical Hodgkin lymphoma HL. Evaluated on data from two scanners to test the reliability of each feature, different feature methods. 23812. https: //doi.org/10.1038/s41598-022-24227-0 PET/CT response for the treatment of advanced-stage marginal lymphoma. In interim FDG-PET scans in lymphoma response assessment in international guidelines Nylla Shanthly1, Anu Eapen3 and D.K international on... Handout on lymphoma, written by the scientific editors of MDPI journals from around the world and other. Of chemotherapy predicts progression-free and overall survival in high-grade non-Hodgkin lymphoma were followed up with clinical examinations and biochemical (... Rate of false positive uptake recommendations by the authors of this article this accounted 26! 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