Atypical manifestations, such as cholestasis, chronic hepatitis, precipitation of acute-on-chronic liver failure, and autoimmune hepatitis, are reported with EBV infection, whereas cholestasis, portal vein thrombosis, and Budd-Chiari syndrome are reported with CMV infection. Tell your doctor about all your current medicines and any medicine you start or stop using. To make ovulation happen at the right time in your menstrual cycle, youll take letrozole for a few days after the start of your period. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. Letrozole is also prescribed off-label for certain types of infertility. Both letrozole and clomiphene are used to treat infertility in females* by helping to cause ovulation. Additionally, sometimes you may receive letrozole by itself after youve had treatment with radiation or surgery. Your GP will be able to monitor and treat this if necessary. Letrozole may be used with other therapies in your breast cancer treatment plan. Letrozole (Femara) can cause side effects similar to menopausal symptoms, like hot flashes, night sweats, and headaches. Continue reading. Mild pain relief such as paracetamol may help with headaches. 2. And its often prescribed together with a form of the hormone progestin. You may report side effects to FDA at 1-800-FDA-1088. More serious side effects are possible, including bone fractures and complications from high cholesterol. eHealthMe is studying from 40,330 Letrozole users for its effectiveness, alternative drugs and more. Its also not recommended to use letrozole while nursing because safety and efficacy studies are lacking. I was checked for an infection but that came back clear. Lifestyle changes suggested for relieving hot flashes could also help with night sweats. 1. This rapid growth of cells can cause a tumor to form in your breast. tamoxifen, which is another breast cancer medication. If you're having trouble, your doctor may prescribe a drug called letrozole. Instead, this response is a shift in your hormone levels that happens when you stop taking letrozole. Avoid driving or hazardous activity until you know how letrozole will affect you. With approval from my oncologist and urogyn, I use a small amount of . Your healthcare provider may recommend taking calcium with vitamin D or a medication called Prolia (denosumab) to strengthen your bones while using letrozole. Holding the ice pack or heating pad on your head for about 10 minutes a few times a day when youre having a headache is recommended. You may feel like your heart is racing (heart palpitations) when taking letrozole, which is more common in older people. Letrozole works by blocking the action of the enzyme aromatase, which prevents the body from converting androgens into estrogens. If you have diarrhoea, its important to drink enough fluids. Bring someone with you to your appointment if doing so will help you feel more comfortable. You should not use letrozole if you are allergic to it. Nausea is a common side effect of many medications, including letrozole. If you think you have fatigue, tell your GP or treatment team. Some reports may have incomplete information. Letrozole oral tablets are a generic drug, which means theyre an exact copy of the active drug in a brand-name medication. You will need frequent medical tests, and your bone mineral density may also need to be checked. You shouldnt take letrozole while youre pregnant or breastfeeding. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. This is when part of the blood clot breaks away and travels to the lung. They can assess you and offer advice on how to manage your energy levels. They work by decreasing the amount of the hormone estrogen in your body. If the pain is severe, it may be helpful to see a pain management specialist at a pain clinic. In clinical trials, more than half of people taking this medication experienced increased cholesterol levels. (2022). For information about the difference between sex and gender, see this article. Swallow the tablet with a drink of water. Abdel-Qadir, H., et al. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. In fact, this was a common side effect in studies of letrozole. Like hot flashes, night sweats can happen when estrogen levels are low. Dont take more letrozole oral tablets than your doctor prescribes. Medicine Assistance Tool and NeedyMeds are two websites that provide resources to help reduce the cost of letrozole oral tablets. The tablets come in one strength: 2.5 milligrams (mg). (2021). Its most often used if youve gone though menopause and have already received other breast cancer treatments, such as surgery or radiation. Their risk is higher because of the cancer itself and some treatments for breast cancer. Data are scarce concerning the influence of these drugs on serum lipid levels. Vaginal bleeding can happen in the first few weeks after starting letrozole. Tiredness and lack of energy may occur. Learn how CBCs are used in the treatment of breast cancer. The most common side-effects of treatment are hot flushes, sweating, joint pain, and feeling tired. Blood clots can be harmful but are treatable so its important to report symptoms as soon as possible. 39,784 people reported to have side effects when taking Letrozole. Your breast care nurse may also be able to offer support or tell you about support services in your area. ), If youre taking letrozole to induce ovulation, using intrauterine insemination (IUI) may help you become pregnant better than having timed sex will. This enzyme changes androgen hormones (like testosterone) found in skin, muscle, and fat cells into estrogen. Letrozole is the generic version of the brand-name drug Femara. Nausea and vomiting Letrozole may also make you feel sick (nausea) or be sick (vomiting). Legro, R. S., et al. Lowering your level of estrogen helps stop your breast cancer from growing. Speak to your GP or treatment team if you have any of these symptoms. This withdrawal response isnt the same as withdrawal that happens when your body becomes dependent on a drug and stopping the drug causes symptoms. Speak with your healthcare provider if youre concerned about any weight changes you experience. Lets review. Ditropan (oxybutynin)." The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. If dizziness persists see your GP. It's done to reduce the risk of cancer in people with a high risk of developing breast, Breast cancer can cause breast pain, but its not common. I have been on Anastrozole for 3 years and bladder pain has become my top issue. Mild pain relief such as paracetamol may help with headaches. (2022). Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. To learn about the cancers letrozole treats, see the What is letrozole used for? section above. The Oxytrol for Women (oxybutynin) patch is available without a prescription to treat those with an overactive bladder, which can cause incontinence problems and make women run to the. New England Journal of Medicine. Warnings You should not use letrozole if you are pregnant. Letrozole can harm an unborn baby. If you are having difficulty accessing this website, please call or email us at (855) 268-2822 or ada@goodrx.com so that we can provide you with the services you require through alternative means. So, letrozole doesnt need to be gradually stopped. This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment. You may also experience weight gain with letrozole if you have swelling, which is another possible side effect of the drug. Letrozole can interact with tamoxifen. visible water retention temporary redness of face and neck weight gain headache nausea generalized weakness drug-induced hot flashes INFREQUENT side effects If experienced, these tend to have a. Hormone therapy for breast cancer. Also, you can apply an ice pack or heat pad to your head to help ease the headache. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. You may also experience side effects caused by other treatments or individual circumstance, such as the menopause. I . Letrozole is also prescribed off-label for certain types of infertility. Letrozole can be taken with or without food. I would also like to sign up for a free GoodRx account, Written by Ross Phan, PharmD, BCACP, BCGP, BCPS, Written by Nicole E. Cieri-Hutcherson, PharmD, BCPS, NCMP, Written by Sonja Jacobsen, PharmD, BCPS, BCOP. Stopping smoking and doing regular weight-bearing exercise can also help keep your bones strong. Letrozole is an oral medication known as an aromatase inhibitor. HOW DOES LETROZOLE WORK? For information about drug-condition interactions, see Other warnings in the What should be considered before taking letrozole? section below. Stopping letrozole isnt known to cause withdrawal symptoms or any other side effects. Since inflammation may be associated with joint pain, adding turmeric (mixed with freshly ground black pepper and olive oil for bioavailability) to foods or taking supplements may help relieve symptoms. These drugs are both forms of hormone therapy for breast cancer. To help relieve headaches with letrozole, you can take over-the-counter (OTC) medications. Talk with your doctor if you have more questions about the differences and similarities between letrozole and tamoxifen. Use the medicine exactly as directed. Letrozole can sometimes cause headaches. Letrozole (Femara) can cause fatigue, dizziness, and sleepiness. Food doesnt interact with letrozole. Follow all directions on your prescription label and read all medication guides or instruction sheets. Most side effects of letrozole are mild and temporary, lasting only a few days or weeks until your body gets used to taking the medication. Available for Android and iOS devices. Letrozole is used to treat breast cancer in postmenopausal women. These symptoms usually improve or become easier to manage over time. Letrozole oral tablets may not be right for you if you have certain medical conditions or other factors that affect your health. O 0. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Although not all of these side effects may occur, if they do occur they may need medical attention. Some of these include bone fractures and complications from high cholesterol. GoodRx works to make its website accessible to all, including those with disabilities. However, the ovarian follicle's response to FSH is only a part of the endocrine events occurring in a developing follicle. Check with your doctor immediately if any of the following side effects occur while taking oxybutynin: More common Bladder pain blistering, crusting, irritation, itching, or reddening of the skin bloody or cloudy urine burning, skin rash, swelling, soreness, redness, pain, itching, or irritation at the application site cracked, dry, or scaly skin Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Letrozole may also be used for purposes not listed in this medication guide. These side effects can often be managed with lifestyle changes. Store at room temperature away from moisture and heat. Additionally, letrozole may be prescribed for females* with both endometriosis and infertility because it can help cause ovulation. (IUI is a procedure in which a sample of sperm is placed directly into the uterus.). They may recommend ways to help reduce the pain. While there are some natural supplements available over the counter to treat hot flashes, these arent recommended in this case. Your healthcare provider will likely check your cholesterol levels when starting letrozole and then regularly while taking it. It is used to treat breast cancer in women who have gone through menopause. Because letrozole lowers estrogen levels, it can cause bone loss as a side effect. Other factors that affect your health will be able to offer support or tell you about services. Be used for a drug and stopping the drug by helping to cause symptoms. Treat breast cancer a pain management specialist at a pain management specialist at a pain clinic,... Will help you feel sick ( vomiting ) about the difference between sex and gender see! Or stop using frequent medical tests, and feeling tired it is used to treat infertility in females * both. Night sweats letrozole lowers estrogen levels, it can cause side effects to FDA at 1-800-FDA-1088 and regularly... 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